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Abbreviations:

GLP = Good Laboratory Practice
SVHC = Substances of Very High Concern*
REACH = Registration, Evaluation, Authorisation and Restriction of Chemicals**
OECD
=
Organisation for Economic Co-operation and Development

* SVHC substances are carcinogenic, mutagenic or toxic for reproduction (CMR cat. 1 and 2), persistent, bioaccumulative and toxic substances. Furthermore, there are substances that "scientific evidence of probable cause serious effects on human health or the environment."

A substance of very high concern (SVHC) is a chemical substance (or part of a group of chemical substances) for which it has been proposed that the use within the European Union be subject to authorisation under the REACH Regulation.[1] Indeed, listing of a substance as an SVHC by the European Chemicals Agency (ECHA) is the first step in the procedure for restriction of use of a chemical. The first list of SVHCs was published on 28 October 2008 and and the SVHC list is now updated regularly with new SVHC substances.

** Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) is a European Union regulation dated 18 December 2006.[1] REACH addresses the production and use of chemical substances, and their potential impacts on both human health and the environment. Its 849 pages took seven years to pass, and it has been described as the most complex legislation in the Union's history[2] and the most important in 20 years.[3] It is the strictest law to date regulating chemical substances and will affect industries throughout the world.[4] REACH entered into force in 1 June 2007, with a phased implementation over the next decade. The regulation also established the European Chemicals Agency, which manages the technical, scientific and administrative aspects of REACH.